What are two methods of targeting and applying management profiles to System Manager clients?

The correct answer is B and D. These are the two methods of targeting and applying management profiles to System Manager clients, according to the [System Manager: Getting Started] article. The article explains that:

Defining the scope: This method allows you to target devices based on their network, tag, or owner. You can define the scope of a profile from the Systems Manager > Manage > Settings page or from the Systems Manager > Monitor > Overview page.

Using device tags: This method allows you to target devices based on their attributes, such as OS, model, location, or user. You can use device tags to create dynamic groups of devices that share common characteristics. You can apply device tags from the Systems Manager > Monitor > Devices page or from the Systems Manager > Manage > Tags page.