A clinical trial where participants will be randomized to receive a sequence of two medications...

A crossover study design involves participants receiving multiple interventions sequentially, with a washout period in between to minimize carryover effects. This design allows each participant to serve as their own control, increasing statistical power while reducing variability. It is commonly used when comparing two treatments or interventions.

GCP guidelines classify a crossover design as one where subjects receive multiple treatments in a specified sequence.

"In crossover trials, participants receive each intervention in a specific order, allowing for within-subject comparison."

Objectives:

Understand the structure of crossover studies.

Improve statistical efficiency through self-control comparisons.