A hospital is experiencing an increase in vancomycin-resistant Enterococcus (VRE) infections in the hematology-oncology unit.

Comprehensive and Detailed In-Depth Explanation:

Hand hygiene remains the single most effective intervention to prevent the spread of vancomycin-resistant Enterococcus (VRE) in healthcare settings. Implementing an audit and feedback system significantly improves compliance and reduces VRE transmission​.

Step-by-Step Justification:

Hand Hygiene Compliance Audit and Feedback (Best Strategy)

Studies show that poor hand hygiene is the primary mode of VRE transmission in hospitals.

Implementing real-time auditing with feedback ensures sustained compliance and helps identify weak areas​.

Why Other Options Are Incorrect:

A. Screening all patients and isolating VRE-positive patients:

While screening helps identify carriers, contact precautions alone are not sufficient without strong hand hygiene enforcement​.

B. Restricting vancomycin use:

While antimicrobial stewardship is crucial, vancomycin use alone does not drive VRE outbreaks—poor infection control practices do.

D. Conducting environmental sampling weekly:

Routine sampling is not necessary; immediate terminal disinfection and improved hand hygiene are more effective.

CBIC Infection Control References:

APIC Text, "VRE Prevention and Hand Hygiene," Chapter 11​.

APIC-JCR Workbook, "Antimicrobial Resistance and Infection Control Measures," Chapter 7​.