Sentinel events are most often the result of variations in:

Comprehensive and Detailed Explanation From Exact Extract:

Within the Patient Safety domain, sentinel events are typically traced to process failures — breakdowns in how care is delivered, coordinated, or monitored.

Root cause analyses of sentinel events frequently reveal that system-level process design, not individual error or competence, is the main contributing factor.

Examples include communication failures, inadequate handoffs, or lack of standardized procedures.

Structural issues or staffing shortages may contribute indirectly, but process variation remains the predominant source of sentinel events in healthcare.