Clients report that they cannot reach the virtual server vs-production on port 80, but are...

The issue is caused by the Source Address restriction configured on the virtual server.

Source Filter: The configuration contains the line source 192.168.0.0/16. This acts as an implicit Access Control List (ACL). The virtual server will only accept and process TCP connections if the client's source IP address falls within the 192.168.x.x range.

Why Ping Works: ICMP (Ping) is handled by the Virtual Address object, not the Virtual Server object. Unless ICMP is specifically disabled on the Virtual Address, it will respond to pings from any subnet, even if the Virtual Server itself is restricted by a source filter or is even disabled.

Evaluation of Other Options:

Disabled (Option A): If the VS were disabled, the configuration would typically show disabled or state down, and the symptoms would be similar, but the source filter is a more specific "misconfiguration" in this context.

Port 80 (Option C): The configuration destination 10.99.20.50:http explicitly confirms it is listening on port 80.

Unallowed Subnet: If a client from a different network (e.g., 10.10.1.5) tries to connect, the BIG-IP will silently drop the connection or send a reset because it does not match the defined source criteria.