An IdentityNow engineer has set up an access profile for an application.

Yes, it is possible to remove the approval requirement for an application in IdentityNow by editing the access profile and unchecking the 'Required Approval' box. This configuration change would eliminate the need for a manager or other approver to review access requests, allowing users to be granted access without requiring approval.

Key Reference from SailPoint Documentation:

Access Profile Configuration: Access profiles can be configured to require or not require approval for access requests, and this option can be modified directly in the profile settings.