A 2-year-old boy is brought by his parents to your clinic because of sudden onset...

Primary herpetic gingivostomatitis caused by HSV-1 is common in toddlers. It presents with high fever, irritability, drooling, refusal to eat, and painful oral ulcers on the lips, gums, and tongue. Cervical lymphadenopathy is common.

Toronto Notes 2023 – Pediatrics, “Infectious Conditions in Children”:

“Primary HSV-1 infection in children presents with high fever, cervical lymphadenopathy, and painful oral ulcers (gingivostomatitis).”

MCCQE1 Objectives (Pediatrics > 75-2: Infectious Diseases):

“Candidates must recognize viral exanthems and enanthems, including herpetic gingivostomatitis, based on clinical findings.”

Kawasaki (A) includes conjunctivitis, strawberry tongue, and extremity changes. Epiglottitis (B) presents with drooling but without oral ulcers. Mono (C) lacks the ulcerative pattern. Hand-foot-mouth (D) affects palms and soles, not inner lips and gums predominantly.

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