A 32-year-old woman presents to the office with questions related to the mRNA vaccines that...

The most important pre-vaccination history to elicit is any previous anaphylaxis to vaccine components. mRNA COVID-19 vaccines (e.g., Pfizer-BioNTech and Moderna) may contain polyethylene glycol (PEG), a potential allergen. This is a contraindication to administration.

Toronto Notes 2023 – Infectious Disease & Immunization Chapter:

“Absolute contraindications to mRNA COVID-19 vaccination include a documented anaphylactic reaction to a component of the vaccine such as polyethylene glycol (PEG).”

MCCQE1 Objectives – Population Health > Preventive Medicine > Immunizations:

“The candidate must be able to assess for contraindications prior to immunization, including anaphylaxis to previous vaccines or components.”

Breastfeeding and occupational exposure (Options B and D) do not preclude vaccination. Current immunosuppression (Option C) may affect vaccine efficacy but is not a contraindication unless specifically advised.

====================================================