You are seeing a 78-year-old man for follow-up of metastatic cholangiocarcinoma diagnosed 8 months ago...

This patient exhibits classic symptoms of a major depressive episode (MDE): anhedonia, low mood, social withdrawal, feelings of worthlessness, hypersomnia, and loss of appetite. These symptoms are persistent and pervasive beyond what is typical in grief.

Toronto Notes 2023 – Psychiatry, “Depressive Disorders” Section:

“MDE is characterized by ≥5 symptoms present nearly every day for ≥2 weeks including low mood, anhedonia, sleep/appetite disturbances, low energy, feelings of worthlessness, and suicidal ideation. It must cause significant impairment in functioning.”

MCCQE1 Objectives (Psychiatry > 79-1: Mood Disorders):

“Candidates must distinguish between grief, adjustment disorders, and major depression in patients with chronic illness and initiate appropriate management.”

Normal grief (A) may involve sadness and crying but does not involve pervasive hopelessness or worthlessness. Side effects of chemotherapy (C) and hepatic encephalopathy (E) have other specific physical signs. Brain metastasis (D) would more likely present with focal neurologic symptoms or cognitive impairment.

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