You have a Microsoft 365 E5 subscription.

To onboard the devices to Microsoft Defender for Endpoint, you need to create an endpoint detection and response (EDR) policy in the Microsoft Intune admin center. This policy enables EDR capabilities on devices that are enrolled in Intune and allows you to configure various settings for EDR functionality. You can then assign the policy to groups of users or devices. References: https://docs.microsoft.com/en-us/mem/intune/protect/edr-windows