An administrator needs to configure a license server to be accessible by Frame desktops.

Frame is a cloud-based desktop-as-a-service platform that allows users to access Windows applications and desktops from any device1. A license server is a server that hosts a network licensing manager for software that requires licenses to run2. Frame supports using a utility server as a license server for Frame desktops1. A utility server is a stand-alone, general purpose Windows server that can be configured and managed from the Frame dashboard1.

https://docs.frame.nutanix.com/platform/admin/utility-servers/