Users are reporting that their desktops are running slower than expected in an ESXi-based Nutanix...

A high CPU Ready time means that the vCPU is waiting too long for the pCPU, which can result in poor performance and slow responsiveness of the virtual machine (VM).

According to Nutanix best practices2, one of the factors that can affect CPU Ready time is the host power policy. The host power policy determines how aggressively the host will try to save power by reducing the frequency or voltage of the pCPUs.

The recommended host power policy for Nutanix clusters is High Performance, which disables any power saving features and ensures that the pCPUs run at their maximum frequency and voltage.

This answer seems to explain why desktops on one host are running slower and have higher CPU Ready times than on other hosts, as they may be suffering from reduced pCPU performance due to a lower host power policy.