A medical company wants to perform transformations on a large amount of clinical trial data...

AWS Glue jobs are designed for extract, transform, and load (ETL) operations, which are perfect for transforming clinical trial data. AWS Glue integrates with AWS Key Management Service (KMS), allowing for customer-specific encryption keys, fulfilling the encryption requirement with minimal operational effort. Client-side encryption with AWS KMS ensures that the data is encrypted before it is sent to S3, aligning with the security needs specified in the scenario.

Key aspects:

AWS Glue: This managed ETL service simplifies data transformation, reduces operational overhead, and integrates seamlessly with KMS.

CSE-KMS: Client-side encryption with KMS ensures that the data is encrypted with customer-specific keys before it is processed or stored in S3, offering robust security​​.

Minimal Operational Overhead: Compared to managing an EMR cluster, AWS Glue automates much of the process, making it a lower-effort solution.

AWS Documentation: According to the AWS Well-Architected Framework, encryption with AWS KMS offers strong security controls that meet the needs of industries requiring high levels of confidentiality​​.