Which component of a contrast agent causes a marked mismatch in impedance between the agent...

Contrast agents used in ultrasound imaging typically consist of microbubbles filled with gas. The significant mismatch in acoustic impedance between the gas in the microbubbles and the surrounding blood creates strong reflectors of the ultrasound waves, enhancing the echogenicity of blood and improving the visibility of blood flow and tissue perfusion. The high contrast provided by the gas-filled microbubbles makes them particularly effective as ultrasound contrast agents.